General Information

  • ID:  hor002292
  • Uniprot ID:  P91736
  • Protein name:  Hydra-LWamide l
  • Gene name:  LOC100192300
  • Organism:  Hydra vulgaris (Hydra) (Hydra attenuata)
  • Family:  LWamide neuropeptide family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Hydra (genus), Hydridae (family), Aplanulata (suborder), Anthoathecata (order), Hydroidolina (subclass), Hydrozoa (class), Cnidaria (phylum), Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  NA

Sequence Information

  • Sequence:  GPPPGLW
  • Length:  7
  • Propeptide:  MGMFERKKIVLLVSLICVSQQATNVQDANSKSTSTELKVVKPQKRVTPVKDAEKLSILRTQDNSLDLNTNGEEVWDELTHNIPLEYIEKIYNELNQLAQNENRPKRLWGATAAINTDNLNPEVENELENKKNAPVIEKFERPIGLWHKDIETKNPENRLPLGLWGKDSEPLPIGLWGKDADVNDDLKKEPLPIGLWGKDTDSTRGDNKPNAYKGKLPIGLWGKDNALTNDLGKKNNGKDSGPPPGLWGKDSKPIPGLWGKDNGPMTGLWGKKDVGPPPGLWGKKDQPPIGMWGRAGKRDSNPYPGLWGKKEEELENVDKEIEEDSLEEFPACLLENPPCEIQEKRYNIDKSGPPPGLWGKRSEKYQMNKPPWRGGMWGRSEILENSVHDSKKTNTIDMEHAEN
  • Signal peptide:  MGMFERKKIVLLVSLICVSQQ
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P91736-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor002292_AF2.pdbhor002292_ESM.pdb

Physical Information

Mass: 83004 Formula: C36H50N8O8
Absent amino acids: ACDEFHIKMNQRSTVY Common amino acids: P
pI: 6.11 Basic residues: 0
Polar residues: 2 Hydrophobic residues: 2
Hydrophobicity: -38.57 Boman Index: 913
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 55.71
Instability Index: 9742.86 Extinction Coefficient cystines: 5500
Absorbance 280nm: 916.67

Literature

  • PubMed ID:  9048780
  • Title:  Molecular Cloning of a Preprohormone From Hydra Magnipapillata Containing Multiple Copies of Hydra-L Wamide (Leu-Trp-NH2) Neuropeptides: Evidence for Processing at Ser and Asn Residues